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Project 10 Prof. Manfred Jung

NAD+ analogues and mimics as tools for chemical biology and as potential drugs

The main focus of this project is to develop cofactor mimics of NAD+ targeted towards NAD+-dependent histone deacetylases (sirtuins) from S. mansoni. Synthetic optimization of screening hits should lead to potent and species-selective inhibitors.
The specific aims are to i) synthesize analogues of the identified lead structure and optimize them in a bioguided fashion, ii) screen further NAD+-biased libraries using virtual screens to identify new lead structures, and iii) optimize potential new lead structures from screening approaches.

Figure 1: Sirtuins and NAD+-dependent lysine deacetylases can be inhibited by mimics of adenosine resp. nicotinamide



Prof. Dr. Manfred Jung

Institute of Pharmaceutical Sciences

Pharmaceutical and Medicinal Chemistry

Albertstr. 25

79104 Freiburg

Phone: +49 (0) 761 203-4896

Fax: +49 (0) 761 203-6351

email: manfred.jung@pharmazie.uni-freiburg.de


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