Uni-Logo
Sektionen
Sie sind hier: Startseite RTG1976 open positions 2018
Artikelaktionen

open positions 2018

  • Doctoral researcher position for Project P2, starting as soon as possible

 

P2: Structure and Function of a Membrane-bound Metalloprotein Complex, Prof. Dr. Susana Andrade, Institute of Biochemistry, University Freiburg
A metalloprotein complex involved in acrylate/methacrylate reduction (respiration) will be studied. This project will combine structural and kinetic data to understand how electrons are conducted from the quinone pool to the flavin active site where the enzymatic degradation of methacrylate, a strictly man-made molecule present in plastics and resins, occurs.
The selected student will learn how to heterologously express, purify and reconstitute membrane proteins in liposomes. Specific techniques such as stopped-flow, freeze-fracture/TEM, cryo-EM, protein crystallography, MST/ITC are available. Preference will be given to students that had previous experience in protein purification, protein crystallography or kinetic work. We offer an excellent opportunity to engage into an exciting PhD project that combines biochemical, biophysical and structural biology tools in the context of a dynamic and enthusiastic work environment, with state-of-the-art equipment and various chances for national and international scientific collaborations.

Requirements:

  • excellent graduates in the fields of pharmacy, chemistry, biology, biochemistry, biotechnology (Master or equivalent)
  • proven interest in one or more of the above indicated research fields
  • highly motivated and committed
  • interested in participating actively in the program of the RTG
  • very good written and spoken English skills

For application, please provide the following documents

  • a cover letter stating your interests and why you want to become part of the RTG,why you think you would fit into this project
  • your curriculum vitae
  • your degree certificates and study transcripts with a description of the grading scheme
  • an abstract (maximum 1 page) of your diploma or master thesis
  • a list of your publications, if available
  • addresses of two potential references and, if available, letters of recommendation
  • a tangible proof of your fluency in English, i.e. certificate (TOEFL, Camebridge certificate, IELTS); German “Abitur” is eligible as proof of fluency in English

 

All documents should be provided in English.
Please submit the above mentioned documents as one PDF file.

Applications can be send directly via Email to
susanne.elfert@pharmazie.uni-freiburg.de
 

The three‐year structured program consists of lecture series, PhD seminars, workshops, symposia and retreats. In addition, participants will have the possibility to attend courses for individual need. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English. 


The duration of the doctoral position is limited to three years. The salary is in accordance with the German public service salary scale (TV‐L E13, 65%).  


 Please refer to “Application RTG 1976-P2” in the subject line. 

 

  • Doctoral researcher position for Project P10, starting November 2018 or later

 

·      P10:  Synthesis and biochemical testing of inhibitors of histone deacetylases, specifically the NAD dependent deacetylase smSirt2 from Schistosoma mansoni.

We will work on the synthesis and biochemical in-vitro testing of inhibitors of histone deacetylases, specifically the NAD dependent deacetylase smSirt2 from Schistosoma mansoni. The assays will involve established fluorescence based in-vitro assays using acetylated, but also long-chain acylated substrates previously synthesized and characterized in our group. We have already identified small molecule hits for inhibition of smSirt2 and established the synthesis. Now we aim to perform bio-guided optimization in feedback loop using medicinal chemistry, biochemistry and anti-parasitic testing (the latter by collaborators). We also aim to establish Proteolysis targeting chimeras (PROTACs) using prior knowledge on such protein degradation agents that we have obtained on human sirtuins.

 The threeyear structured program consists of lecture series, PhD seminars, workshops, symposia and retreats. In addition, participants will have the possibility to attend courses for individual need. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.

 

Requirements:

·     excellent graduates in the fields of pharmacy, chemistry, biology, biochemistry, biotechnology (Master or equivalent)

·         proven interest in one or more of the above indicated research fields

  • highly motivated and committed
  • interested in participating actively in the program of the RTG
  • very good written and spoken English skills 

The duration of the PhD position is limited to three years. The salary is in accordance with the German public service salary scale (TVL E13, 65%).  

The following documents are required for your application as PhD student:

  • a cover letter stating your interests and why you want to become part of the RTG, preference for one project and why you think you would fit into this project
  • your curriculum vitae
  • your degree certificates and study transcripts with a description of the grading scheme
  • an abstract (maximum 1 page) of your diploma or master thesis
  • a list of your publications, if available
  • addresses of two potential references and, if available, letters of recommendation
  • a tangible proof of your fluency in English, i.e. certificate (TOEFL, Cambridge certificate, IELTS); German “Abitur” is eligible as proof of fluency in English

 

All documents should be provided in English.
Please submit the above-mentioned documents as one PDF file.

Interested candidates should send their application containing the required documents as one pdf file only to susanne.elfert@pharmazie.uni-freiburg.de. Applications will be considered until position is filled. Please refer to “Application RTG 1976-P10” in the subject line.  


 

Benutzerspezifische Werkzeuge