Project 9 Prof. Manfred Jung
NAD+ analogues and mimics as tools for chemical biology and as potential drugs
The main focus of this project is to develop cofactor mimics of NAD+ targeted towards NAD+-dependent histone deacetylases (sirtuins) from S. mansoni. Synthetic optimization of screening hits should lead to potent and species-selective inhibitors.
The specific aims are to i) synthesize analogues of the identified lead structure and optimize them in a bioguided fashion, ii) screen further NAD+-biased libraries using virtual screens to identify new lead structures, and iii) optimize potential new lead structures from screening approaches.
Figure 1: Sirtuins and NAD+-dependent lysine deacetylases can be inhibited by mimics of adenosine resp. nicotinamide
Contact
Prof. Dr. Manfred Jung
Institute of Pharmaceutical Sciences
Pharmaceutical and Medicinal Chemistry
Albertstr. 25
79104 Freiburg
Phone: +49 (0) 761 203-4896
Fax: +49 (0) 761 203-6351
email: manfred.jung@pharmazie.uni-freiburg.de
http://www.pharmazie.uni-freiburg.de/chemie/german/professoren/akjunghp/arbeitskreis.htm