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Publications of RTG 1976 doctoral reserchers 2014-2019:

Birth D, Kao WC, Hunte C (2014) Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat Commun 5, 4029

Greule A, Marolt M, Deubel D, Peintner I, Zhang S, Jessen-Trefzer C, De Ford C, Burschel S, Li SM, Friedrich T, Merfort I, Lüdeke S, Bisel P, Müller M, Paululat T, Bechthold A (2017) Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties. Front Microbiol 21, 8-22.
Nohr D, Rodriguez R, Weber S, Schleicher E (2015) How can EPR spectroscopy help to unravel molecular mechanisms of flavin-dependent photoreceptors? Front Mol Biosci Sep 1;2:49
Nohr D, Franz S, Rodriguez R, Paulus B, Essen LO, Weber S, Schleicher E (2016) Extended electron-transfer pathways in animal cryptochromes mediated by a tetrad of aromatic amino acids, Biophys J 111, 301-311
Nohr D, Paulus B, Rodriguez R, Okafuji A, Bittl R, Schleicher E, Weber S (2017) Determination of Radical–Radical Distances in Light-Active Proteins and Their Implication for Biological Magnetoreception, Angewandte Chemie Int Ed  7, 56, 8550–8554
Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL (2018) Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures. Proc Natl Acad Sci USA, 115, 3350–3355
Pervaiz M, Mishra P, Günther (2018) S. Bromodomains: promising targets for drug discovery. Book chapter, Epigenetic Targets in Drug Discovery.  Wiley in press
Präg A, Grüning BA, Erxleben A, Häckh M, Lüdeke S, Wilde M, Luzhetskyy A, Richter M, uzhetska M, Günther S, Müller M (2014) Regio- and Stereoselective Intermolecular Oxidative Phenol Coupling in Streptomyces, J Am Chem Soc, 136, 6195–6198
Sheppard DMW, Li J, Henbest KB, Neil SRT, Maeda K, Storey J, Schleicher E, Biskup T, Rodriguez R, Weber S, Hore P J, Timmel CR, Mackenzie SR (2017) Millitesla magnetic field effects on the photocycle of an animal cryptochrome, Sci Rep 7, Art.-No. 42228
Sommer-Kamann C, Fries A, Mordhorst S, Andexer JN, Müller M (2017) Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM. Angew Chem Int Ed 56, 4033–4036
Zierep PF, Padilla N, Yonchev DG, Telukunta KK, Klementz D, Günther S (2017) SeMPI:  a genome-based secondary metabolite prediction and identification web server. Nucleic Acids Res 45, W64-W71
Klementz D, Döring K, Lucas X, Telukunta KK, Erxleben A, Deubel D, Erber A, Santillana I, Thomas OS, Bechthold A, Günther S (2016) StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes. Nucleic Acids Res 44, 509-514
Mergelsberg M, Willistein M, Meyer H, Stärk HJ, Bechtel DF, Pierik AJ, Boll M (2017) Phthaloyl-CoA decarboxylase from Thauera chlorobenzoica: the prenylated flavin, K+, - and Fe2+-dependent key enzyme of anaerobic phthalate degradation. Environ Microbiol, 19, 3734-3744
Mordhorst S, Siegrist J, Müller M, Richter M, Andexer JN (2017) Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System. Angew Chem Int Ed 56, 4037–4041
Siegrist J, Aschwanden S, Mordhorst S, Thöny-Meyer L, Richter M, Andexer JN (2015) Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades. ChemBioChem 16, 2576–2579
Siegrist J, Netzer J, Mordhorst S, Karst L, Gerhardt S, Einsle O, Richter M, Andexer JN (2017) Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity. FEBS Lett 591, 312–321
Spatzal T, Schlesier J, Burger EM, Sippel D, Zhang L, Andrade SLA, Rees DC, Einsle O (2016) Nitrogenase FeMoco investigated by spatially-resolved anomalous dispersion refinement. Nat Commun 7, 10902
Swyter S, Schiedel M, Monaldi D, Szunyog S, Lehotzky A, Rumpf T, Ovádi J, Sippl W,  Jung (2018) New chemical tools for probing activity and inhibition of the NAD+ dependent lysine deacylase sirtuin 2. Phil Trans R Soc B, in press
Sippel D, Rohde M, Netzer J, Trncik C, Gies J, Grunau K, Djurdjevic I, Decamps L, Andrade SLA, Einsle O (2018) A bound reaction intermediate reveals details on substrate reduction by nitrogenase. Science, 359:1484-1489
Estelmann S, Blank I, Feldmann A, Boll M (2015) Two distinct old yellow enzymes are involved in naphthyl ring reduction during anaerobic naphthalene degradation. Mol Microbiol 95,162-72
Gnandt E, Schimpf J, Harter C, Hoeser J, Friedrich T (2017) Reduction of the off-pathway iron-sulphur cluster N1a of Escherichia coli respiratory complex I restrains NAD+ dissociation. Sci Rep 7, 8754
Gnandt E, Dörner K, Strampraad MFJ, de Vries S, Friedrich T (2016) The multitude of iron-sulfur clusters in respiratory complex I. Biochim Biophys Acta, 1857, 1068-1072
Haas J, Häckh M, Justus V, Müller M, Lüdeke S (2017) Addition of a polyhistidine tag alters the regioselectivity of carbonyl reductase S1 from Candida magnoliae. Org Biomol Chem 15, 10256-10264
Haas J, Schätzle MA, Husain SM, Schulz-Fincke J, Jung M, Hummel W, Müller M, Lüdeke S (2016) A quinone mediator drives oxidations catalyzed by alcohol dehydrogenase-containing cell lysates. Chem Commun 52, 5198–5201
Hoeser J, Gnandt E, Friedrich, T (2018) Low cost, multi-wavelength microcontroller based differential scanning fluorimetry. Sci Rep 8, 1457
Houwaart S, Youssar, L, Hüttel W (2014) Pneumocandin biosynthesis: Involvement of a trans-selective proline hydroxylase.  ChemBioChem 15, 2365–69
Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung  M, Breit B, Günther S, Wohlwend D (2017) Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew Chem Int Ed 56, 12476-12480